Artichoke Spinach Grilled Cheese

Featured in: Fresh & Warm Skillet Meals

This indulgent grilled cheese sandwich combines the beloved flavors of spinach-artichoke dip with perfectly melted cheese between crispy sourdough slices. The filling features a blend of cream cheese, mozzarella, Monterey Jack, and Parmesan mixed with fresh spinach and artichoke hearts, seasoned with garlic and a hint of heat.

Preparation is simple: mix the creamy filling, spread onto bread slices, butter the exterior, and pan-fry until golden and melted. Each sandwich takes just 10 minutes to cook, making this an ideal weeknight meal. Serve warm, optionally sliced, alongside tomato soup or a fresh green salad for a complete dining experience.

Updated on Tue, 20 Jan 2026 13:11:00 GMT
Golden sourdough slices embrace a warm, melted artichoke spinach grilled cheese filling for a comforting vegetarian lunch.  Pin It
Golden sourdough slices embrace a warm, melted artichoke spinach grilled cheese filling for a comforting vegetarian lunch. | cedarlemon.com

My roommate Sarah and I discovered this combination during a rainy week when all we had was sourdough bread and leftover spinach artichoke dip from a party. We spread the dip on bread, grilled it up, and honestly our tiny kitchen smelled like a restaurant.

Now whenever friends visit, they specifically ask for that spinach artichoke grilled cheese. Last month my brother actually requested them for his birthday dinner instead of going out to eat.

Ingredients

  • Fresh spinach: Fresh wilts down beautifully but frozen works perfectly fine if you thaw and squeeze it really well first
  • Artichoke hearts: Canned jarred ones are tender and briny just drain them thoroughly so your sandwich does not get soggy
  • Cream cheese: Soften this to room temperature so it blends smoothly into the other cheeses without leaving chunks
  • Mozzarella cheese: This provides the incredible stretch factor when you bite into the hot sandwich
  • Monterey Jack or Swiss cheese: Either melts beautifully and adds a mild nutty flavor that complements the artichokes
  • Grated Parmesan cheese: A little goes a long way adding that salty umami punch that makes the filling feel rich
  • Unsalted butter: Softened butter spreads more evenly than cold and gives the bread that golden restaurant style crust
  • Sourdough bread: The tangy flavor and sturdy texture holds up to the hearty filling without falling apart
  • Garlic clove: One small clove minced finely is all you need to perfume the filling
  • Black pepper: Freshly ground adds brightness that cuts through all that creamy cheese
  • Crushed red pepper flakes: Totally optional but a tiny pinch adds warmth without making it spicy
  • Salt: Just a pinch since the cheeses already bring plenty of saltiness

Instructions

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Measure spices, liquids, and baking ingredients accurately for consistent results in cooking and baking.
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Mix the filling:
Toss everything together in a bowl until the cheeses coat the spinach and artichokes evenly.
Assemble sandwiches:
Spread the mixture on four slices and top with remaining bread to make four complete sandwiches.
Butter the bread:
Coat the outside of each sandwich generously with softened butter on both sides.
Grill until golden:
Cook in a hot skillet for about 4 minutes per side until the bread turns golden brown and the cheese melts completely.
Rest and serve:
Let the sandwiches sit for a minute before slicing so the filling sets slightly.
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A close-up of a sliced artichoke spinach grilled cheese reveals creamy dip-inspired layers, perfect with a bowl of tomato soup.  Pin It
A close-up of a sliced artichoke spinach grilled cheese reveals creamy dip-inspired layers, perfect with a bowl of tomato soup. | cedarlemon.com

These sandwiches have become my go to comfort food when the weather turns gray and I need something warming but do not have the energy for an elaborate dinner project.

Making Ahead

I have learned to mix up the filling the night before and keep it in the refrigerator. Actually the flavors meld together overnight and taste even better the next day.

Bread Selection

Thick cut sourdough works best but any sturdy bread will do. Just avoid very soft sandwich bread because it will turn to mush under all that cheese filling.

Serving Suggestions

A simple tomato soup or crisp green salad turns this into a complete meal that feels special enough for company.

  • Sun dried tomatoes add a chewy sweetness that plays nicely with the artichokes
  • Chopped scallions bring a fresh bite right at the end
  • A dollop of marinara sauce on the side for dipping never hurt anyone
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Buttery, crisp sourdough encases a savory artichoke spinach grilled cheese, served beside fresh greens for a balanced meal. Pin It
Buttery, crisp sourdough encases a savory artichoke spinach grilled cheese, served beside fresh greens for a balanced meal. | cedarlemon.com

There is something deeply satisfying about turning appetizer dip into a real meal that sticks to your ribs.

Recipe Questions & Answers

Can I prepare the filling ahead of time?

Yes, the artichoke-spinach filling can be made up to 2 days in advance and stored in an airtight container in the refrigerator. This makes assembly quick on serving day.

What bread alternatives work best?

While sourdough provides excellent texture and flavor, whole wheat bread adds nutritional benefits, and gluten-free varieties accommodate dietary needs. Any sturdy bread that can withstand pan-frying works well.

How do I prevent the filling from leaking out?

Spread the filling evenly but not too close to the bread edges, leaving about ½ inch margin. Cook over medium heat and avoid high temperatures that cause rapid melting and leakage.

Can I add other ingredients to the filling?

Absolutely. Sun-dried tomatoes, chopped scallions, roasted red peppers, or caramelized onions complement the spinach-artichoke base beautifully without requiring technique adjustments.

What cheese combination works if I don't have all varieties listed?

You can substitute with any combination of melting cheeses. Cheddar, gruyere, or fontina work well. The key is balancing moisture from cream cheese with the melting quality of other cheeses.

How should I serve this sandwich?

Serve immediately while the cheese is still warm and creamy. Pairing with tomato soup creates classic comfort food, while a crisp green salad provides a fresh contrast to the rich, savory filling.

Artichoke Spinach Grilled Cheese

Golden sourdough grilled cheese featuring creamy spinach-artichoke dip filling with melted cheese blend.

Prep Time
15 min
Cook Duration
10 min
Time Required
25 min
Created by Victoria Reed


Skill Level Easy

Cuisine American

Makes 4 Portions

Special Diets Meat-Free

What You'll Need

Vegetables

01 1 cup fresh spinach, chopped (or 1/2 cup frozen, thawed and drained)
02 1 cup canned or jarred artichoke hearts, drained and chopped

Dairy

01 4 oz cream cheese, softened
02 1/2 cup shredded mozzarella cheese
03 1/2 cup shredded Monterey Jack or Swiss cheese
04 1/4 cup grated Parmesan cheese
05 2 tablespoons unsalted butter, softened

Bread

01 8 slices sourdough bread

Seasonings

01 1 small garlic clove, minced
02 1/4 teaspoon black pepper
03 1/8 teaspoon crushed red pepper flakes, optional
04 Pinch of salt

How-To Steps

Step 01

Prepare the filling: In a mixing bowl, combine softened cream cheese, mozzarella, Monterey Jack, Parmesan, chopped spinach, artichoke hearts, minced garlic, black pepper, red pepper flakes, and salt. Mix until well blended.

Step 02

Assemble sandwiches: Lay out sourdough slices and spread artichoke-spinach mixture evenly onto 4 slices. Top each with a remaining bread slice to form sandwiches.

Step 03

Butter exterior: Lightly butter the outside of each sandwich on both sides using softened butter.

Step 04

Cook sandwiches: Heat a large skillet or griddle over medium heat. Place sandwiches in the pan and cook 3 to 4 minutes per side, pressing gently, until bread is golden brown and cheese is melted.

Step 05

Rest and serve: Remove from skillet and let rest for 1 minute. Slice diagonally and serve warm.

Tools You'll Need

  • Mixing bowl
  • Spoon or spatula
  • Knife and cutting board
  • Skillet or griddle
  • Spatula for flipping

Allergy Notes

Review ingredients for allergens and ask your provider if you have concerns.
  • Contains dairy: cheese and butter
  • Contains wheat from bread
  • May contain soy depending on bread and cheese brands
  • Check labels for potential cross-contamination with severe allergies

Nutrition Details (each serving)

Details are for general information and not a substitute for professional guidance.
  • Energy: 410
  • Total Fat: 23 g
  • Carbohydrates: 38 g
  • Protein: 15 g